High frequency stimulation of the subthalamic nucleus acutely rescues motor deficits and neocortical movement representations following 6-hydroxydopamine administration in rats
Identifieur interne : 001942 ( Main/Exploration ); précédent : 001941; suivant : 001943High frequency stimulation of the subthalamic nucleus acutely rescues motor deficits and neocortical movement representations following 6-hydroxydopamine administration in rats
Auteurs : Andrew R. Brown [Canada] ; Michael C. Antle [Canada] ; BIN HU [Canada] ; G. Campbell Teskey [Canada]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cartographie.
English descriptors
- KwdEn :
Abstract
Loss of frontal neocortical activation is one of the main neurophysiological abnormalities of Parkinson's disease (PD) and can be observed in rodent models of nigrostriatal degeneration. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus improves motor deficits in PD. However, it is unknown whether this general therapeutic effect is associated with a restoration of frontal output function. To address this question, chronic stimulating electrodes were implanted bilaterally into the subthalamic nuclei of adult rats that received either bilateral intrastriatal 6-hydroxydopamine (6-OHDA) or vehicle infusion to induce nigrostriatal degeneration. Forelimb use and locomotor activity were assessed based on the cylinder and open field tests in intact, post-lesion + sham DBS, and post-lesion + DBS conditions. Intracortical microstimulation was then used to probe frontal output function of forelimb motor areas. DBS was found to improve motor deficits arising from 6-OHDA lesions, increase forelimb map area, and decrease movement thresholds relative to baseline. These effects were significantly greater in 6-OHDA lesion rats compared to vehicle controls. Results indicate that changes in motor map expression can take place during subthalamic DBS following dopamine depletion in a rodent model of PD.
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Brown</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Antle, Michael C" sort="Antle, Michael C" uniqKey="Antle M" first="Michael C." last="Antle">Michael C. Antle</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychology, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Physiology and Pharmacology, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Bin Hu" sort="Bin Hu" uniqKey="Bin Hu" last="Bin Hu">BIN HU</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Clinical Neurosciences, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Teskey, G Campbell" sort="Teskey, G Campbell" uniqKey="Teskey G" first="G. Campbell" last="Teskey">G. Campbell Teskey</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychology, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Physiology and Pharmacology, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Cell Biology and Anatomy, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author></analytic><series><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Cartography</term><term>Deep brain stimulation</term><term>Dopamine</term><term>High frequency</term><term>Motor nucleus</term><term>Motor system disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Rat</term><term>Representation</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Haute fréquence</term><term>Noyau sousthalamique</term><term>Noyau moteur</term><term>Représentation</term><term>Animal</term><term>Rat</term><term>Cartographie</term><term>Dopamine</term><term>Stimulation cérébrale profonde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cartographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Loss of frontal neocortical activation is one of the main neurophysiological abnormalities of Parkinson's disease (PD) and can be observed in rodent models of nigrostriatal degeneration. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus improves motor deficits in PD. However, it is unknown whether this general therapeutic effect is associated with a restoration of frontal output function. To address this question, chronic stimulating electrodes were implanted bilaterally into the subthalamic nuclei of adult rats that received either bilateral intrastriatal 6-hydroxydopamine (6-OHDA) or vehicle infusion to induce nigrostriatal degeneration. Forelimb use and locomotor activity were assessed based on the cylinder and open field tests in intact, post-lesion + sham DBS, and post-lesion + DBS conditions. Intracortical microstimulation was then used to probe frontal output function of forelimb motor areas. DBS was found to improve motor deficits arising from 6-OHDA lesions, increase forelimb map area, and decrease movement thresholds relative to baseline. These effects were significantly greater in 6-OHDA lesion rats compared to vehicle controls. Results indicate that changes in motor map expression can take place during subthalamic DBS following dopamine depletion in a rodent model of PD.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Brown, Andrew R" sort="Brown, Andrew R" uniqKey="Brown A" first="Andrew R." last="Brown">Andrew R. Brown</name></region><name sortKey="Antle, Michael C" sort="Antle, Michael C" uniqKey="Antle M" first="Michael C." last="Antle">Michael C. Antle</name><name sortKey="Antle, Michael C" sort="Antle, Michael C" uniqKey="Antle M" first="Michael C." last="Antle">Michael C. Antle</name><name sortKey="Antle, Michael C" sort="Antle, Michael C" uniqKey="Antle M" first="Michael C." last="Antle">Michael C. Antle</name><name sortKey="Bin Hu" sort="Bin Hu" uniqKey="Bin Hu" last="Bin Hu">BIN HU</name><name sortKey="Bin Hu" sort="Bin Hu" uniqKey="Bin Hu" last="Bin Hu">BIN HU</name><name sortKey="Teskey, G Campbell" sort="Teskey, G Campbell" uniqKey="Teskey G" first="G. Campbell" last="Teskey">G. Campbell Teskey</name><name sortKey="Teskey, G Campbell" sort="Teskey, G Campbell" uniqKey="Teskey G" first="G. Campbell" last="Teskey">G. Campbell Teskey</name><name sortKey="Teskey, G Campbell" sort="Teskey, G Campbell" uniqKey="Teskey G" first="G. Campbell" last="Teskey">G. Campbell Teskey</name><name sortKey="Teskey, G Campbell" sort="Teskey, G Campbell" uniqKey="Teskey G" first="G. Campbell" last="Teskey">G. Campbell Teskey</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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